One-month zero-order sustained release and tumor eradication after a single subcutaneous injection of interferon alpha fused with a body-temperature-responsive polypeptide-Reference-Cited by-同舟云学术

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One-month zero-order sustained release and tumor eradication after a single subcutaneous injection of interferon alpha fused with a body-temperature-responsive polypeptide

Published:2019 Issue:1 Volume:7 Page:104-112
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Wang Zhuoran¹²³⁴⁵,Guo Jianwen¹²³⁴⁵,Ning Jing⁶⁷⁸⁹⁵,Feng Xiaoyu⁶⁷⁸⁹⁵,Liu Xinyu¹²³⁴⁵,Sun Jiawei¹²³⁴⁵,Chen Xiangmei⁶⁷⁸⁹⁵,Lu Fengmin⁶⁷⁸⁹⁵,Gao Weiping¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biomedical Engineering

2. School of Medicine

3. Tsinghua University

4. Beijing 100084

5. China

6. Department of Microbiology & Infectious Disease Center

7. School of Basic Medical Sciences

8. Peking University Health Science Center

9. Beijing 100191

Abstract

Upon a single subcutaneous injection, IFN-ELP in situ forms a depot, leading to one-month sustained release and dramatically enhanced tumor therapy.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/BM/C8BM01096J

Reference37 articles.

1. Protein therapeutics: a summary and pharmacological classification

2. Biopharmaceutical benchmarks 2010

3. Clinical Pharmacokinetics of Interferons

4. Improving protein therapeutics with sustained-release formulations

5. Synthesis of well-defined protein–polymer conjugates for biomedicine

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