Downregulation of m<sup>6</sup>A demethylase ALKBH5 promotes AuNP-induced neural stem cell quiescence <i>via</i> regulating ID4 expression-Reference-Cited by-同舟云学术

Downregulation of m⁶A demethylase ALKBH5 promotes AuNP-induced neural stem cell quiescence via regulating ID4 expression

Published:2023 Issue:3 Volume:10 Page:843-854
ISSN:2051-8153
Container-title:Environmental Science: Nano
language:en
Short-container-title:Environ. Sci.: Nano

Author:

Huang Xiaofeng¹²,Yang Renjun¹²,Qi Zijuan¹³,Wang Xudong¹²,Yin Nuoya¹²,Faiola Francesco¹²^ORCID,Liu Sijin¹²^ORCID,Gao Ming¹²^ORCID

Affiliation:

1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China

2. College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100085, China

3. Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji'nan 250014, Shandong, China

Abstract

Gold nanoparticles (AuNPs) enhanced the N6-methyladenosine (m6A) modification via downregulation of the expression of ALKBH5, leading to increased ID4 expression in an IGF2BP3 dependent manner and subsequent neural stem cells (NSCs) quiescence.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Science Fund for Creative Research Groups

Youth Innovation Promotion Association

Publisher

Royal Society of Chemistry (RSC)

Subject

General Environmental Science,Materials Science (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/EN/D2EN00734G

Reference33 articles.