Nanoscale mineralization of cell-laden methacrylated gelatin hydrogels using calcium carbonate–calcium citrate core–shell microparticles

Author:

Subbiah Ramesh1ORCID,Balbinot Gabriela de Souza12,Athirasala Avathamsa3,Collares Fabricio Mezzomo2ORCID,Sereda Grigoriy4,Bertassoni Luiz E.1356ORCID

Affiliation:

1. Division of Biomaterials and Biomechanics, Department of Restorative Dentistry, School of Dentistry, Oregon Health and Science University, Portland, OR 97201, USA

2. Department of Dental Materials, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil

3. Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR 97201, USA

4. Department of Chemistry, University of South Dakota, Vermillion, SD 57069, USA

5. Center for Regenerative Medicine, School of Medicine, Oregon Health and Science University, Portland, OR 97201, USA

6. Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA

Abstract

Bone-like scaffolds were developed using a facile microparticles-assisted nanoscale mineralization of human mesenchymal stem cell-laden hydrogels.

Funder

National Institute of Dental and Craniofacial Research

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Burroughs Wellcome Fund

Oregon Clinical and Translational Research Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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