A QM/MM study of Kemptide phosphorylation catalyzed by protein kinase A. The role of Asp166 as a general acid/base catalyst
Author:
Affiliation:
1. Institut de Biotecnologia i de Biomedicina and Departament de Química
2. Universitat Autònoma de Barcelona
3. 08193 Bellaterra (Barcelona)
4. Spain
Abstract
QM/MM calculations show that Asp166 is a general acid/base catalyst along the phosphoryl and proton transfer steps of Kemptide phosphorylation by protein kinase A.
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2015/CP/C4CP03579H
Reference75 articles.
1. The Protein Kinase Complement of the Human Genome
2. Kinase Drug Discovery – What’s Next in the Field?
3. Kinetic and Catalytic Mechanisms of Protein Kinases
4. Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase
Cited by 17 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation;Science;2023-09-15
2. Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation;2022-07-04
3. Investigation of the Detailed AMPylated Reaction Mechanism for the Huntingtin Yeast-Interacting Protein E Enzyme HYPE;International Journal of Molecular Sciences;2021-06-29
4. How a Second Mg2+ Ion Affects the Phosphoryl-Transfer Mechanism in a Protein Kinase: A Computational Study;ACS Catalysis;2020-12-15
5. How does evolution design functional free energy landscapes of proteins? A case study on the emergence of regulation in the Cyclin Dependent Kinase family;Molecular Systems Design & Engineering;2020
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3