Facile synthesis of chiral 2-functionalized tetrahydroquinolines <i>via</i> Pd/Cu-catalyzed cascade γ-C(sp<sup>3</sup>)–H arylation/C–N coupling of amides derived from amino acids and their derivatives-Reference-Cited by-同舟云学术

Facile synthesis of chiral 2-functionalized tetrahydroquinolines via Pd/Cu-catalyzed cascade γ-C(sp³)–H arylation/C–N coupling of amides derived from amino acids and their derivatives

Published:2023 Issue:17 Volume:10 Page:4388-4393
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Yu Dian¹²³,Peng Si-Yuan⁴,Wang Han¹²³,Zheng Qiu-Cui¹²³,Ma Ya-Hui¹²³,Xiao Dong-Yi¹²³,Li Qian-Li⁵,Wang Wen-Shu¹²³,Cui Xiao-Jie¹²³,Luo Fei-Xian¹²³^ORCID

Affiliation:

1. Key Laboratory of Ecology and Environment in Minority Areas (Minzu University of China), National Ethnic Affairs Commission, Beijing, 100081, China

2. College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China

3. Center for Bioimaging & System Biology, Minzu University of China, Beijing, 100081, China

4. Department of Chemistry, Capital Normal University, Beijing, 100048, China

5. School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252000, China

Abstract

We successfully explored a one-pot strategy to synthesize valuable chiral 2-functionalized tetrahydroquinoline motifs through the precise modification of amides derived from commercially available natural amino acids.

Funder

Beijing Municipal Natural Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00884C

Reference45 articles.

1. Synthesis of 1,2,3,4-Tetrahydroquinolines including Angustureine and Congeneric Alkaloids. A Review

2. Advances in the Chemistry of Tetrahydroquinolines

3. Progress in the Chemistry of Tetrahydroquinolines

4. Asymmetric Hydrogenation of Heteroarenes and Arenes

5. Selective homogeneous hydrogenation of benzothiophene and quinoline catalysed by ruthenium, osmium, rhodium and iridium complexes