Ultrasensitive detection of the H5N1 nucleic acid fragment by ICP-MS using DNA dendrimer-carried silver nanoparticle labeling

Author:

Huang Chao123ORCID,Jiao Yanni4,Shao Lijun4,Li Wei4,Ding Shengyong2,Jiang Dafeng4ORCID,Jiang Wei1ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, Shandong University, 250100 Jinan, P. R. China

2. Department of Pharmacy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, P. R. China

3. College of Pharmacy, Shandong University of Traditional Chinese Medicine, 250355 Jinan, P.R. China

4. Shandong Academy of Preventive Medicine, Shandong Center for Food Safety Risk Assessment, Shandong Center for Disease Control and Prevention, 250014 Jinan, P. R. China

Abstract

Ultrasensitive detection of the H5N1 nucleic acid fragment by ICP-MS using DNA dendrimer-carried AgNP labeling was developed. This approach enabled significant signal amplification, while magnetic separation effectively suppressed background signals.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

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