Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation-Reference-Cited by-同舟云学术

Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

Published:2018 Issue:16 Volume:47 Page:5548-5552
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Dong Jingran¹²³⁴⁵,Tian Hongwu¹²³⁴⁵,Song Changying¹²³⁴⁵,Shi Tiesheng¹²³⁴⁵^ORCID,Elding Lars I.⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. College of Chemistry and Environmental Science

2. and the MOE Key Laboratory of Medicinal Chemistry and Molecular Diagnostics

3. Hebei University

4. Baoding 071002

5. People's Republic of China

6. Center for Analysis and Synthesis

7. Department of Chemistry

8. Lund University

9. SE-221 00 Lund

10. Sweden

Abstract

Reduction of the Pt(iv) anticancer active prodrug ormaplatin by an extended series of thiols has been studied, revealing a remarkable linear free-energy correlation.

Funder

Hebei University

Natural Science Foundation of Hebei Province

Kungliga Fysiografiska Sällskapet i Lund

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/DT/C8DT00852C

Reference37 articles.

1. The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

2. Platinum(IV) Prodrugs – A Step Closer to Ehrlich's Vision?

3. Research progress in modern structure of platinum complexes

4. Oxidation of 3,6-Dioxa-1,8-octanedithiol by Platinum(IV) Anticancer Prodrug and Model Complex: Kinetic and Mechanistic Studies

5. Finely Tuned Asymmetric Platinum(IV) Anticancer Complexes: Structure-Activity Relationship and Application as Orally Available Prodrugs

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