Synthesis of difluoromethylated enynes by the reaction of α-(trifluoromethyl)styrenes with terminal alkynes-Reference-Cited by-同舟云学术

Synthesis of difluoromethylated enynes by the reaction of α-(trifluoromethyl)styrenes with terminal alkynes

Published:2018 Issue:38 Volume:16 Page:6909-6917
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wu Mingsheng¹²³⁴⁵,Zhao Xianghu¹²³⁴⁵,Liu Yisen¹²³⁴⁵,Cao Song¹²³⁴⁵^ORCID

Affiliation:

1. Shanghai Key Laboratory of Chemical Biology

2. School of Pharmacy

3. East China University of Science and Technology (ECUST)

4. Shanghai 200237

5. China

Abstract

A novel and efficient method for the synthesis of difluoromethylated enynes by the reaction of α-(trifluoromethyl)styrenes with terminal alkynes with the assistance of NaOtBu was developed.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02117A

Reference72 articles.

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2. Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

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4. Catalytic Asymmetric Construction of Stereogenic Carbon Centers that Feature agem-Difluoroalkyl Group

5. Ligand-Controlled Copper-Catalyzed Highly Regioselective Difluoromethylation of Allylic Chlorides/Bromides and Propargyl Bromides

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