Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease-Reference-Cited by-同舟云学术

Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease

Published:2019 Issue:22 Volume:10 Page:5815-5820
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Linder Thomas¹²³⁴^ORCID,Liu Rongxia⁵⁶⁷⁴^ORCID,Atanasov Atanas G.⁵⁶⁷⁴^ORCID,Li Yuanfang⁵⁶⁷⁴^ORCID,Geyrhofer Sophie¹²³⁴,Schwaiger Stefan⁸⁹¹⁰¹¹⁴^ORCID,Stuppner Hermann⁸⁹¹⁰¹¹⁴^ORCID,Schnürch Michael¹²³⁴^ORCID,Dirsch Verena M.⁵⁶⁷⁴^ORCID,Mihovilovic Marko D.¹²³⁴^ORCID

Affiliation:

1. Institute of Applied Synthetic Chemistry

2. TU Wien

3. 1060 Vienna

4. Austria

5. Department of Pharmacognosy

6. University of Vienna

7. 1090 Vienna

8. Institute of Pharmacy/Pharmacognosy

9. Center for Molecular Biosciences Innsbruck

10. University of Innsbruck

11. 6020 Innsbruck

Abstract

The first total synthesis of the edelweiss constituent leoligin is reported, together with the first pharmacological evaluation of the parent compound and some of its analogs.

Funder

Austrian Science Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC00446G

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