Importance of the main chain of lysine for histone lysine methyltransferase catalysis-Reference-Cited by-同舟云学术

Importance of the main chain of lysine for histone lysine methyltransferase catalysis

Published:2019 Issue:23 Volume:17 Page:5693-5697
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Al Temimi Abbas H. K.¹²³⁴^ORCID,Teeuwen Ruben S.¹²³⁴^ORCID,Tran Vu¹²³⁴,Altunc Arthur J.¹²³⁴,Lenstra Danny C.¹²³⁴,Ren Wansheng⁵⁶⁷,Qian Ping⁵⁶⁷,Guo Hong⁸⁹¹⁰¹¹,Mecinović Jasmin¹²³⁴¹²^ORCID

Affiliation:

1. Institute for Molecules and Materials

2. Radboud University

3. 6525 AJ Nijmegen

4. The Netherlands

5. Chemistry and Material Science Faculty

6. Shandong Agricultural University

7. P.R. China

8. Department of Biochemistry & Cellular and Molecular Biology

9. University of Tennessee

10. Knoxville

11. USA

12. Department of Physics, Chemistry and Pharmacy

Abstract

Enzymatic and computational studies on the simplest lysine analogues that possess a modified main chain demonstrate that the lysine's backbone contributes significantly to functional KMT binding and catalysis.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01038F

Reference23 articles.

1. Chemical and Biochemical Perspectives of Protein Lysine Methylation

2. Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact