Nano-enzyme hydrogels for cartilage repair effectiveness based on ternary strategy therapy-Reference-Cited by-同舟云学术

Nano-enzyme hydrogels for cartilage repair effectiveness based on ternary strategy therapy

Published:2024 Issue:25 Volume:12 Page:6242-6256
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Deng Wei¹²,Zhou Yue³,Wan Qinlin⁴,Li Lei⁵^ORCID,Deng Hui⁶,Yin Yong²,Zhou Qingsong²,Li Qiujiang¹,Cheng Duo²,Hu Xuefeng⁶^ORCID,Wang Yunbing⁵^ORCID,Feng Ganjun¹^ORCID

Affiliation:

1. Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, 17 Gaopeng Avenue, Chengdu 610041, China

2. Department of Orthopedics, Pidu District People's Hospital, The Third Affiliated Hospital of Chengdu Medical College, Chengdu, 611730, China

3. Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China

4. Medical College of Soochow University, Suzhou, 215123, China

5. National Engineering Research Center for Biomaterials & College of Biomedical Engineering, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan, 610065, China

6. West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, China

Abstract

An artificial nano-enzyme-enhanced hydrogel was developed to treat OA through a ternary synergistic strategy of efficiently driving O2 production from endogenous ROS in chondrocytes and maintaining lubrication at the articular cartilage interface.

Funder

National Natural Science Foundation of China

Sichuan Province Science and Technology Support Program

Chengdu University of Information Technology

West China Hospital, Sichuan University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D4TB00307A

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