Phenylalanyl tRNA synthetase (PheRS) substrate mimics: design, synthesis, molecular dynamics and antimicrobial evaluation-Reference-Cited by-同舟云学术

Phenylalanyl tRNA synthetase (PheRS) substrate mimics: design, synthesis, molecular dynamics and antimicrobial evaluation

Published:2022 Issue:4 Volume:12 Page:2511-2524
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Noureldin Nada A.¹²^ORCID,Richards Jennifer³,Kothayer Hend²^ORCID,Baraka Mohammed M.²,Eladl Sobhy M.²^ORCID,Wootton Mandy³,Simons Claire¹^ORCID

Affiliation:

1. School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK

2. Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig P. C., 44519, Egypt

3. Specialist Antimicrobial Chemotherapy Unit, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, UK

Abstract

Nineteen novel compounds were designed to mimic Phe-AMP, as a new hope to find novel antibacterial agents and combat the antibiotic resistance. E. faecalis PheS homology model was constructed to study the mimics–enzyme interactions in more detail.

Funder

Ministry of Higher Education

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D1RA06439H

Reference29 articles.

1. The Ongoing Threat of Antimicrobial Resistance

2. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis

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