A versatile method for the selective core-crosslinking of hyaluronic acid nanogels via ketone-hydrazide chemistry: from chemical characterization to in vivo biodistribution

Author:

Garcia Francielle Pelegrin12345,Rippe Marlène1234,Companhoni Mychelle V. P.56789,Stefanello Talitha Fernandes12345,Louage Benoit10111213,Van Herck Simon10111213,Sancey Lucie1415164ORCID,Coll Jean-Luc1415164ORCID,De Geest Bruno G.10111213ORCID,Vataru Nakamura Celso56789,Auzély-Velty Rachel1234ORCID

Affiliation:

1. Grenoble Alpes University

2. Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS)

3. 38041 Grenoble Cedex 9

4. France

5. Laboratory of technological innovation in the development of pharmaceuticals and cosmetics

6. State

7. University of Maringa

8. Maringa

9. Brazil

10. Department of Pharmaceutics

11. Ghent University

12. 9000 Ghent

13. Belgium

14. Institute for Advanced Biosciences

15. Grenoble Alpes University/INSERM U1209/CNRS UMR5309

16. Grenoble

Abstract

Nanogels show long in vivo blood circulation time and high tumor accumulation.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Financiadora de Estudos e Projetos

Agence Nationale de la Recherche

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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