Increasing the bioactive space of peptide macrocycles by thioamide substitution-Reference-Cited by-同舟云学术

Increasing the bioactive space of peptide macrocycles by thioamide substitution

Published:2018 Issue:9 Volume:9 Page:2443-2451
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Verma Hitesh¹²³⁴^ORCID,Khatri Bhavesh¹²³⁴^ORCID,Chakraborti Sohini¹²³⁴^ORCID,Chatterjee Jayanta¹²³⁴⁵^ORCID

Affiliation:

1. Molecular Biophysics Unit

2. Indian Institute of Science

3. Bangalore 560012

4. India

5. NMR Research Centre

Abstract

Thioamide substitution into macrocyclic peptides increases the conformational rigidity of the backbone resulting in enhanced biological activity and metabolic stability.

Funder

Science and Engineering Research Board

Department of Biotechnology, Ministry of Science and Technology

Ministry of Human Resource Development

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC04671E

Reference77 articles.

1. Tools and rules for macrocycles

2. Macrocycles: lessons from the distant past, recent developments, and future directions

3. Strategies for transitioning macrocyclic peptides to cell-permeable drug leads

4. Cyclic peptide therapeutics: past, present and future

5. The exploration of macrocycles for drug discovery — an underexploited structural class

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