Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer-Reference-Cited by-同舟云学术

Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer

Published:2016 Issue:3 Volume:4 Page:394-408
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Dickerson Matthew¹²³⁴⁵,Howerton Brock⁵²³⁴,Bae Younsoo⁵²³⁴,C. Glazer Edith¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Kentucky

3. Lexington

4. USA

5. Department of Pharmaceutical Sciences

Abstract

Cross-linked polymeric nanoassemblies are potential carrier systems for cytotoxic ruthenium complexes, and exhibit a combination of electrostatic and hydrophobic interactions with the metal complexes that impact release rates, release percentages, and biological activity.

Funder

National Cancer Institute

American Cancer Society

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2016/TB/C5TB01613D

Reference50 articles.

1. Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents

2. Modifying Charge and Hydrophilicity of Simple Ru(II) Polypyridyl Complexes Radically Alters Biological Activities: Old Complexes, Surprising New Tricks