A covalent inhibitor of the YAP–TEAD transcriptional complex identified by high-throughput screening
Author:
Affiliation:
1. Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA
2. Calibr, A Division of Scripps Research, La Jolla, CA, 92037, USA
Abstract
Funder
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)
Link
http://pubs.rsc.org/en/content/articlepdf/2023/CB/D3CB00044C
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1. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.
2. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase
3. Shar-pei mediates cell proliferation arrest during imaginal disc growth inDrosophila
4. TEAD mediates YAP-dependent gene induction and growth control
5. The emerging roles of YAP and TAZ in cancer
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