Tandem-catalysis-enabled highly chemoselective deoxygenative alkynylation and alkylation of tertiary amides: a versatile entry to functionalized α-substituted amines-Reference-Cited by-同舟云学术

Tandem-catalysis-enabled highly chemoselective deoxygenative alkynylation and alkylation of tertiary amides: a versatile entry to functionalized α-substituted amines

Published:2022 Issue:12 Volume:9 Page:3237-3246
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wang Xiao-Gang¹,Ou Wei¹²,Liu Mu-Han¹,Liu Zhan-Jiang¹,Huang Pei-Qiang¹^ORCID

Affiliation:

1. Department of Chemistry and Fujian Provincial Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P. R. China

2. SZU-NUS Collaborative Center and International Collaborative Laboratory of 2D Materials for Optoelectronic Science and Technology of Ministry of Education, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China

Abstract

We report a unified relay catalysis strategy for the direct reductive alkynylation and reductive alkylation of tertiary amides to afford α-alkynylamines and α-branched amines.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00335J

Reference69 articles.

1. Organic Synthesis—Where now?

2. Catalytic versus stoichiometric reagents as a key concept for Green Chemistry