One-pot asymmetric synthesis of a hexahydrophenanthridine scaffold containing five stereocenters via an organocatalytic quadruple-cascade reaction-Reference-Cited by-同舟云学术

One-pot asymmetric synthesis of a hexahydrophenanthridine scaffold containing five stereocenters via an organocatalytic quadruple-cascade reaction

Published:2021 Issue:3 Volume:45 Page:1168-1171
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Zhang Xiao-Long¹²³⁴⁵,Feng Kai-Xiang¹²³⁴⁵,Hu Jian-Liang⁶⁷⁵,Shen Qiao-Yu¹²³⁴⁵,Huang Wang-Sheng⁶⁷⁵,Xia Ai-Bao¹²³⁴⁵^ORCID,Li Chen¹²³⁴⁵,Xu Dan-Qian¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology

2. Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province

3. Zhejiang University of Technology

4. Hangzhou 310014

5. P. R. China

6. Hangzhou Grascent Co., Ltd.

7. Meicheng Town 311604

Abstract

An organocatalytic enantioselective aza-Michael-Michael-Michael/aldol cyclization quadruple-cascade reaction of 2-amino-β-nitrostyrenes and α,β-unsaturated aldehydes has been developed for the construction of fully substituted hexahydrophenanthridine.

Funder

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D0NJ03946B

Reference59 articles.

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