Racemization-free and scalable amidation of <scp>l</scp>-proline in organic media using ammonia and a biocatalyst only-Reference-Cited by-同舟云学术

Racemization-free and scalable amidation of l-proline in organic media using ammonia and a biocatalyst only

Published:2022 Issue:13 Volume:24 Page:5171-5180
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Pitzer Julia¹,Steiner Kerstin¹,Schmid Christian¹,Schein Viktor K.²,Prause Christoph²,Kniely Claudia³,Reif Michaela³,Geier Martina¹,Pietrich Elena¹,Reiter Tamara¹²,Selig Philipp⁴,Stückler Clemens⁴,Pöchlauer Peter⁴,Steinkellner Georg¹⁵,Gruber Karl⁵,Schwab Helmut³,Glieder Anton³,Kroutil Wolfgang²^ORCID

Affiliation:

1. ACIB GmbH, Petersgasse 14, 8010 Graz, Austria

2. Department of Chemistry, Organic & Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria

3. Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria

4. Thermo Fisher Scientific Linz, St-Peter-Straße 25, 4020 Linz, Austria

5. Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50, 8010 Graz, Austria

Abstract

This work describes the biocatalytic amidation of l-proline with ammonia, resulting in a process with optimized atom efficiency giving prolinamide in an optically pure form (ee >99%). Detailed enzyme and reaction engineering studies are provided.

Funder

Bundesministerium für Digitalisierung und Wirtschaftsstandort

Steirische Wirtschaftsförderungsgesellschaft

Standortagentur Tirol

Karl-Franzens-Universität Graz

Austrian Centre of Industrial Biotechnology

Österreichische Forschungsförderungsgesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link