Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?-Reference-Cited by-同舟云学术

Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?

Published:2023 Issue:10 Volume:40 Page:1595-1607
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Holland Darren C.¹²^ORCID,Carroll Anthony R.¹²^ORCID

Affiliation:

1. School of Environment and Science, Griffith University, Gold Coast, Australia

2. Griffith Institute for Drug Discovery, Griffith University, Brisbane, Australia

Abstract

Limited screening focus has led to most marine derived indole alkaloids (MIA) being inactive. However, computational comparisons with indole drugs suggest MIAs will be active in new disease relevant targets if a screening focus shift is adopted.

Funder

Australian Government

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NP/D2NP00085G

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