Enzyme-activated near-infrared fluorogenic probe with high-efficiency intrahepatic targeting ability for visualization of drug-induced liver injury-Reference-Cited by-同舟云学术

Enzyme-activated near-infrared fluorogenic probe with high-efficiency intrahepatic targeting ability for visualization of drug-induced liver injury

Published:2021 Issue:44 Volume:12 Page:14855-14862
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhang Yong¹²,Chen Xueqian¹²,Yuan Qing¹²,Bian Yongning¹²,Li Mingrui¹²,Wang Yaling¹²,Gao Xueyun¹²^ORCID,Su Dongdong¹²^ORCID

Affiliation:

1. Department of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology, Beijing, 100124, P. R. China

2. Center of Excellence for Environmental Safety and Biological Effects, Beijing University of Technology, Beijing, 100124, P. R. China

Abstract

We rationally designed a leucine aminopeptidase (LAP) activated fluorogenic probe hCy-CA-LAP with high hepatocyte-targeting ability for accurate and sensitive imaging of DILI.

Funder

National Natural Science Foundation of China

Beijing Municipal Education Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC04825B

Reference60 articles.

1. Recent Progress in Fluorescent Sensors for Drug-Induced Liver Injury Assessment

2. Review article: drug hepatotoxicity

3. Real-Time In Vivo Hepatotoxicity Monitoring through Chromophore-Conjugated Photon-Upconverting Nanoprobes

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