Computational modeling of the catalytic mechanism of hydroxymethylbilane synthase-Reference-Cited by-同舟云学术

Computational modeling of the catalytic mechanism of hydroxymethylbilane synthase

Published:2019 Issue:15 Volume:21 Page:7932-7940
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Bung Navneet¹²³⁴⁵^ORCID,Roy Arijit¹²³⁴,Priyakumar U. Deva⁵⁶⁷⁴^ORCID,Bulusu Gopalakrishnan¹²³⁴⁵^ORCID

Affiliation:

1. TCS Innovation Labs – Hyderabad (Life Sciences Division)

2. Tata Consultancy Services Limited

3. Hyderabad 500081

4. India

5. Center for Computational Natural Sciences and Bioinformatics

6. International Institute of Information Technology

7. Hyderabad 500032

Abstract

Hydroxymethylbilane synthase (HMBS), the third enzyme in the heme biosynthesis pathway, catalyzes the formation of 1-hydroxymethylbilane (HMB) by a stepwise polymerization of four molecules of porphobilinogen (PBG) using the dipyrromethane (DPM) cofactor.

Funder

Department of Biotechnology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CP/C9CP00196D

Reference32 articles.

1. Structure and function of enzymes in heme biosynthesis

2. One ring to rule them all: Trafficking of heme and heme synthesis intermediates in the metazoans

3. Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site

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1. One ring closer to a closure: the crystal structure of the ES₃ hydroxymethylbilane synthase intermediate;The FEBS Journal;2023-11-02

2. The crystal structures of the enzyme hydroxymethylbilane synthase, also known as porphobilinogen deaminase;Acta Crystallographica Section F Structural Biology Communications;2021-10-19

3. Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism;iScience;2021-03

4. Network analysis of hydroxymethylbilane synthase dynamics;Journal of Molecular Graphics and Modelling;2020-09