A pH-independent electrochemical aptamer-based biosensor supports quantitative, real-time measurement in vivo

Author:

Li Shaoguang1ORCID,Ferrer-Ruiz Andrés2ORCID,Dai Jun3ORCID,Ramos-Soriano Javier2ORCID,Du Xuewei1ORCID,Zhu Man1ORCID,Zhang Wanxue1ORCID,Wang Yuanyuan1ORCID,Herranz M. Ángeles2ORCID,Jing Le1ORCID,Zhang Zishuo1ORCID,Li Hui1ORCID,Xia Fan1ORCID,Martín Nazario24ORCID

Affiliation:

1. State Key Laboratory of Biogeology Environmental Geology, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China

2. Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain

3. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China

4. IMDEA-Nanoscience, C/Faraday, 9, Campus de Cantoblanco, 28049 Madrid, Spain

Abstract

An electrochemical aptamer-based sensor, enabling in vivo measurements of drug concentrations directly in the bladder of living rats under pH-variable conditions, was developed employing a π-extended tetrathiafulvalene (exTTF) as redox reported.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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