Structural and biological evaluation of halogen derivatives of 1,9-pyrazoloanthrones towards the design of a specific potent inhibitor of c-Jun-N-terminal kinase (JNK)-Reference-Cited by-同舟云学术

Structural and biological evaluation of halogen derivatives of 1,9-pyrazoloanthrones towards the design of a specific potent inhibitor of c-Jun-N-terminal kinase (JNK)

Published:2018 Issue:13 Volume:42 Page:10651-10660
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Ganduri Ramesh¹²³⁴,Singh Vikas⁵²³⁴,Biswas Ansuman⁶²³⁴,Karothu Durga Prasad¹²³⁴,Sekar Kanagaraj⁷²³⁴,Balaji Kithiganahalli N.⁵²³⁴,Guru Row Tayur N.¹²³⁴^ORCID

Affiliation:

1. Solid State and Structural Chemistry Unit

2. Indian Institute of Science

3. Bangalore 560012

4. India

5. Department of Microbiology and Cell Biology

6. Department of Physics

7. Department of Computational and Data Sciences

Abstract

A specifically designed halogen derivatives of anthrapyrazolone for the selective inhibition of JNKs at lower concentrations with minimal off-target effects on MAPKs.

Funder

Department of Biotechnology, Ministry of Science and Technology

Department of Science and Technology, Ministry of Science and Technology

Council of Scientific and Industrial Research

Indian Council of Medical Research

Indo-French Centre for the Promotion of Advanced Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C8NJ00852C