Releasable and traceless PEGylation of arginine-rich antimicrobial peptides-Reference-Cited by-同舟云学术

Releasable and traceless PEGylation of arginine-rich antimicrobial peptides

Published:2017 Issue:5 Volume:8 Page:4082-4086
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Gong Y.¹²³⁴⁵,Andina D.¹²³⁴⁵,Nahar S.⁶⁷⁸⁹,Leroux J.-C.¹²³⁴⁵,Gauthier M. A.⁶⁷⁸⁹^ORCID

Affiliation:

1. Institute of Pharmaceutical Sciences

2. Department of Chemistry and Applied Biosciences

3. Swiss Federal Institute of Technology Zurich (ETHZ)

4. Zurich 8093

5. Switzerland

6. EMT Research Center

7. Institut National de la Recherche Scientifique (INRS)

8. Varennes J3X 1S2

9. Canada

Abstract

This study reports a strategy to temporarily mask arginine residues within antimicrobial peptides (AMPs) with methoxy poly(ethylene glycol) (mPEG). PEGylation protects AMPs from serum proteases, and can be released at a pharmaceutically-relevant rate. Fully active and unmodified (i.e., native) AMPs are released with time.

Funder

Natural Sciences and Engineering Research Council of Canada

Swiss National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC00770A

Reference26 articles.

1. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

2. Antibacterial peptides: basic facts and emerging concepts