A compact integrated microfluidic oxygenator with high gas exchange efficiency and compatibility for long-lasting endothelialization

Author:

Lachaux Julie1,Hwang Gilgueng1,Arouche Nassim2,Naserian Sina2ORCID,Harouri Abdelmounaim1,Lotito Valeria1ORCID,Casari Caterina3ORCID,Lok Thevy4,Menager Jean Baptiste5,Issard Justin5,Guihaire Julien5,Denis Cécile V.3ORCID,Lenting Peter J.3ORCID,Barakat Abdul I.4,Uzan Georges2,Mercier Olaf5ORCID,Haghiri-Gosnet Anne-Marie1ORCID

Affiliation:

1. Université Paris-Saclay, CNRS, Centre de Nanosciences et Nanotechnologies C2N, UMR9001, Palaiseau 91120, France

2. Université Paris-Saclay, INSERM, UMR-S-MD 1197, Hôpital Paul Brousse, Villejuif, France

3. Université Paris-Saclay, INSERM, UMR S1176, Le Kremin-Bicêtre, France

4. LadHyX, CNRS, Ecole polytechnique, Institut polytechnique de Paris, Palaiseau 91120, France

5. Université Paris-Saclay, INSERM UMR_S 999 “Pulmonary Hypertension: Pathophysiology and Novel Therapies”, Hôpital Marie Lannelongue, Le Plessis-Robinson, France

Abstract

A novel microfluidic architecture allowing simple parallel stacking of the different 4 inch circular units of curved blood capillaries covering a maximal surface area with high compacity is proposed for blood oxygenation at high flow rate.

Funder

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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