Isoindoline-based fluorogenic probes bearing a self-immolative linker for the sensitive and selective detection of O-GlcNAcase activity

Author:

Wu Yuan-Hao1,Wang Guan-Jun1,Guo Chen1,Wang Pei-Pei23ORCID,Wang Jun-Yi4,Hu Xi-Le1ORCID,Zang Yi567ORCID,James Tony D.89ORCID,Li Jia236710ORCID,He Xiao-Peng111ORCID

Affiliation:

1. Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, China

2. National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China

4. Shanghai Starriver Bilingual School, No. 2588 Jindu Road, Minhang District, Shanghai, China

5. Lingang Laboratory, Shanghai 201203, China

6. School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China

7. State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

8. Department of Chemistry, University of Bath, Bath, BA2 7AY, UK

9. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China

10. University of Chinese Academy of Sciences, Beijing, 100049, China

11. The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, National Center for Liver Cancer, Shanghai 200438, China

Abstract

An isoindoline-based fluorogenic probe bearing a self-immolative linker was developed for the sensitive and selective detection of O-GlcNAcase.

Funder

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

State Key Laboratory of Bioreactor Engineering

State Key Laboratory of Drug Research, Chinese Academy of Sciences

School of Chemistry and Chemical Engineering, Shandong University of Science and Technology

Henan Normal University

Publisher

Royal Society of Chemistry (RSC)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3