Deciphering pathological remodelling of the human cartilage extracellular matrix in osteoarthritis at the supramolecular level-Reference-Cited by-同舟云学术

Deciphering pathological remodelling of the human cartilage extracellular matrix in osteoarthritis at the supramolecular level

Published:2022 Issue:24 Volume:14 Page:8691-8708
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Jaabar Ilhem Lilia¹²,Cornette Pauline¹²,Miche Antoine¹,Wanherdrick Kristell²,Dupres Vincent³,Ehkirch François-Paul²⁴,Cambon Binder Adeline²⁵,Berenbaum Francis²⁶,Houard Xavier²,Landoulsi Jessem¹^ORCID

Affiliation:

1. Sorbonne Université, CNRS, Laboratoire de Réactivité de Surface, LRS, F-75005 Paris, France

2. Sorbonne Université, INSERM (UMR_S938), Centre de Recherche Saint-Antoine, CRSA, F-75012 Paris, France

3. Université Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 – UMR 9017 – CIIL – Center for Infection and Immunity of Lille, F-59000, Lille, France

4. Clinique Maussins-Nollet, F-75019 Paris, France

5. Orthopedics and Hand Surgery Department, Saint-Antoine Hospital, 184 Rue du Faubourg Saint-Antoine, Paris, 75012, France

6. Rheumatology Department, AP-HP Saint-Antoine Hospital, 184, rue du Faubourg Saint-Antoine, 75012, Paris, France

Abstract

Osteoarthritis induces a combination of chemical, structural and nanomechanical changes to collagen fibrils and aggrecan aggregates, the main building blocks of cartilage ECM, that may be mimicked by specific enzymatic reactions.

Funder

Sorbonne Université

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D2NR00474G

Reference54 articles.

1. The Basic Science of Articular Cartilage: Structure, Composition, and Function

2. Nanomechanics of the Cartilage Extracellular Matrix