N-tert-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer-Reference-Cited by-同舟云学术

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N-tert-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer

Published:2017 Issue:3 Volume:8 Page:551-558
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Offerman Shaun C.¹²³⁴⁵^ORCID,Kadirvel Manikandan⁶⁵⁷,Abusara Osama H.¹²³⁴⁵^ORCID,Bryant Jennifer L.¹²³⁴⁵,Telfer Brian A.¹²³⁴⁵,Brown Gavin⁶⁵⁷,Freeman Sally¹²³⁴⁵,White Anne⁸⁹¹⁰³⁴,Williams Kaye J.¹²³⁴⁵,Aojula Harmesh S.¹²³⁴⁵^ORCID

Affiliation:

1. Division of Pharmacy and Optometry

2. School of Health Sciences

3. Manchester Academic Health Sciences Centre

4. University of Manchester

5. Manchester

6. CRUK-EPSRC Cancer Imaging Centre in Cambridge and Manchester

7. UK

8. Division of Diabetes, Endocrinology & Gastroenterology

9. School of Medical Sciences

10. Faculty of Biology, Medicine, & Health

Abstract

Prenylated sequences unlocks the development of new therapeutics as demonstrated for an anticancer agent.

Funder

Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C6MD00691D

Reference42 articles.

1. Small Cell Lung Cancer

2. A Review of First-Line Treatment for Small-cell Lung Cancer

3. M. Joshi , A.Ayoola and C.Belani, in Impact of Genetic Targets on Cancer Therapy, ed. W. S. ElDeiry, 2013, vol. 779, pp. 385–404

4. Small-cell lung cancer

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