Organocatalytic formal [3 + 3] cyclization of α-(6-indolyl) propargylic alcohols-Reference-Cited by-同舟云学术

Organocatalytic formal [3 + 3] cyclization of α-(6-indolyl) propargylic alcohols

Published:2022 Issue:32 Volume:20 Page:6334-6338
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yue Zhibin¹,Wang Ziyang¹,Zhang Yunfeng²,Chen Xuling³,Li Pengfei³^ORCID,Li Wenjun¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Qingdao University, Qingdao 266021, China

2. Department of Orthopedics, Qingdao Municipal Hospital, Qingdao, 266011, China

3. Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China

Abstract

A acetic acid mediated 1,10-conjugate addition-mediated formal [3 + 3] cyclization of alkynyl indole imine methides formed in situ from α-(6-indolyl) propargylic alcohols with 1,3-dicarbonyl compounds such as 4-hydroxycoumarins and cyclohexane-1,3-diones was developed.

Funder

Science, Technology and Innovation Commission of Shenzhen Municipality

Natural Science Foundation of Shandong Province

Guangdong Provincial Key Laboratory Of Catalysis

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01206E

Reference43 articles.

1. Comparative inhibitory effect of prenylated coumarins, ferulenol and ferprenin, contained in the ‘poisonous chemotype’ of Ferula communis on mammal liver microsomal VKORC1 activity