In situ nanoscale visualization of solvent effects on molecular crystal surfaces-Reference-Cited by-同舟云学术

In situ nanoscale visualization of solvent effects on molecular crystal surfaces

Published:2021 Issue:16 Volume:23 Page:2933-2937
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Herzberg Mikkel¹²³⁴^ORCID,Larsen Anders S.¹²³⁴^ORCID,Hassenkam Tue⁵²⁶⁴^ORCID,Madsen Anders Ø.¹²³⁴^ORCID,Rantanen Jukka¹²³⁴^ORCID

Affiliation:

1. Department of Pharmacy

2. University of Copenhagen

3. 2100 Copenhagen

4. Denmark

5. Globe Institute

6. 1350 Copenhagen

Abstract

Atomic force microscopy and molecular dynamics simulations probed the crystallinity and hydrophobicity of a paracetamol crystal surface in water–ethanol mixtures. We observe the formation of a dynamic heterogenous disordered surface (DHDS) layer.

Funder

Det Frie Forskningsråd

Villum Fonden

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CE/D1CE00209K

Reference26 articles.

1. AFM studies of the crystallization and habit modification of an excipient material, adipic acid

2. The effects of additives on the growth and morphology of paracetamol (acetaminophen) crystals

3. Adhesion between Molecules and Calcium Oxalate Crystals: Critical Interactions in Kidney Stone Formation

4. Surface Characterization of Aspirin Crystal Planes by Dynamic Chemical Force Microscopy

5. Evidence-Based Nanoscopic and Molecular Framework for Excipient Functionality in Compressed Orally Disintegrating Tablets

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