Selective functionalization of complex heterocycles via an automated strong base screening platform-Reference-Cited by-同舟云学术

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Selective functionalization of complex heterocycles via an automated strong base screening platform

Published:2017 Issue:4 Volume:2 Page:446-450
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Boga Sobhana Babu¹²³⁴⁵,Christensen Melodie⁶²³⁴⁵,Perrotto Nicholas⁶²³⁴⁵,Krska Shane W.¹²³⁴⁵,Dreher Spencer¹²³⁴⁵,Tudge Matthew T.⁶²³⁴⁵,Ashley Eric R.⁶²³⁴⁵,Poirier Marc⁶²³⁴⁵,Reibarkh Mikhail⁶²³⁴⁵,Liu Yong⁶²³⁴⁵,Streckfuss Eric¹²³⁴⁵,Campeau Louis-Charles⁶²³⁴⁵,Ruck Rebecca T.⁶²³⁴⁵,Davies Ian W.⁶²³⁴⁵,Vachal Petr¹²³⁴⁵

Affiliation:

1. Department of Discovery Chemistry

2. MRL

3. Merck & Co., Inc.

4. Rahway

5. USA

6. Department of Process Research & Development

Abstract

An automated high throughput screening approach to optimizing strong base-mediated metalations.

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RE/C7RE00057J

Reference38 articles.

1. Directed ortho metalation. Tertiary amide and O-carbamate directors in synthetic strategies for polysubstituted aromatics

2. The 2×3 Toolbox of Organometallic Methods for Regiochemically Exhaustive Functionalization

3. Multiple Regioselective Functionalizations of Quinolines via Magnesiations

4. Mixed Alkylamido Aluminate as a Kinetically Controlled Base

5. Synthesis of Fully Substituted Pyrazoles via Regio- and Chemoselective Metalations

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