Quinoides and VEGFR2 TKIs influence the fate of hepatocellular carcinoma and its cancer stem cells

Author:

Kahraman Deniz Cansen1234,Hanquet Gilles56789,Jeanmart Loïc10111213,Lanners Steve10111213,Šramel Peter1415161718,Boháč Andrej1415161718,Cetin-Atalay Rengul19202134

Affiliation:

1. Dept. of Mol. Biol. and Gen.

2. Bilkent University

3. Ankara

4. Turkey

5. Laboratoire Syncat

6. UMR CNRS 7509

7. ECPM

8. Université de Strasbourg

9. 67087 Strasbourg

10. Department of Chemistry and Namur Medicine & Drug Innovation Center (NAMEDIC)

11. University of Namur

12. 5000 Namur

13. Belgium

14. Faculty of Natural Sciences

15. Comenius University

16. 842 15 Bratislava (PŠ, AB)

17. Slovakia

18. Biomagi Ltd.

19. Cancer Systems Biology Laboratory

20. Graduate School of Informatics

21. ODTU

Abstract

Bioactivities of quinoides 1–5 and VEGFR2 TKIs 6–10 in hepatocellular cancer (HCC) and cancer stem cells (HCSCs) were studied. Quinoide 3 was able to eradicate cancer stem cells.

Funder

Vedecká Grantová Agentúra MŠVVaŠ SR a SAV

European Cooperation in Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

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