Ornithine-derived oligomers and dendrimers for in vitro delivery of DNA and ex vivo transfection of skin cells via saRNA-Reference-Cited by-同舟云学术

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Ornithine-derived oligomers and dendrimers for in vitro delivery of DNA and ex vivo transfection of skin cells via saRNA

Published:2020 Issue:22 Volume:8 Page:4940-4949
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Saviano Francesca¹²³⁴,Lovato Tatiana⁵⁶⁷⁸,Russo Annapina¹²³⁴,Russo Giulia¹²³⁴,Bouton Clément R.⁹¹⁰¹¹¹²¹³,Shattock Robin J⁹¹⁰¹¹¹²¹³,Alexander Cameron⁵⁶⁷⁸^ORCID,Quaglia Fabiana¹²³⁴^ORCID,Blakney Anna K.⁹¹⁰¹¹¹²¹³^ORCID,Gurnani Pratik⁵⁶⁷⁸^ORCID,Conte Claudia¹²³⁴^ORCID

Affiliation:

1. Department of Pharmacy

2. University of Napoli Federico II

3. 80131 Napoli

4. Italy

5. Division of Molecular Therapeutics and Formulation

6. School of Pharmacy

7. University of Nottingham

8. UK

9. Department of Infectious Disease

10. Imperial College London

11. School of Medicine

12. St Mary's Hospital

13. London W2 1NY

Abstract

Ornithine dendrimers exhibit high activity as vectors for saRNA in cells and skin, highlighting their potential use in RNA vaccines.

Funder

Engineering and Physical Sciences Research Council

European Commission

Regione Campania

Royal Society

Associazione Italiana per la Ricerca sul Cancro

Horizon 2020 Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2020/TB/D0TB00942C

Reference52 articles.

1. Gene Therapy

2. Drug pipeline: 4Q18

3. Delivery technologies for genome editing

4. Gene Therapy for Cancer Treatment: Past, Present and Future

5. Immune Responses to Viral Gene Therapy Vectors

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