LEGO-lipophosphonoxins: length of hydrophobic module affects permeabilizing activity in target membranes of different phospholipid composition-Reference-Cited by-同舟云学术

LEGO-lipophosphonoxins: length of hydrophobic module affects permeabilizing activity in target membranes of different phospholipid composition

Published:2024 Issue:4 Volume:14 Page:2745-2756
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Dugić Milica¹^ORCID,Brzobohatá Hana¹^ORCID,Mojr Viktor²^ORCID,Dolejšová Tereza¹^ORCID,Lišková Petra¹^ORCID,Do Pham Duy Dinh²^ORCID,Rejman Dominik²^ORCID,Mikušová Gabriela¹²^ORCID,Fišer Radovan¹^ORCID

Affiliation:

1. Department of Genetics and Microbiology, Faculty of Science, Charles University, Viničná 5, 128 00 Prague 2, Czech Republic

2. Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences v. v. i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic

Abstract

We developed modular antimicrobial compounds capable of inducing cytoplasmic membrane perforation. This structure–activity relationship study focuses on the role of the length of their alkenyl hydrophobic module.

Funder

Přírodovědecká Fakulta, Univerzita Karlova

Grantová Agentura České Republiky

European Commission

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA07251G

Reference47 articles.

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