Structural basis for tailor-made selective PI3K α/β inhibitors: a computational perspective-Reference-Cited by-同舟云学术

Structural basis for tailor-made selective PI3K α/β inhibitors: a computational perspective

Published:2021 Issue:1 Volume:45 Page:373-382
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Wang Huibin¹²³⁴^ORCID,Wang Ying⁵²³⁴^ORCID,Li Chunshi⁶²³⁴⁷,Wang Hanxun⁶²³⁴⁷,Geng Xiaohui¹²³⁴,Hu Baichun⁶²³⁴⁷,Wen Rui⁶²³⁴⁷,Wang Jian⁶²³⁴⁷^ORCID,Zhang Fengjiao⁵²³⁴^ORCID

Affiliation:

1. School of Pharmacy

2. Shenyang Pharmaceutical University

3. Shenyang 110016

4. People's Republic of China

5. Wuya College of Innovation

6. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education

7. School of Pharmaceutical Engineering

Abstract

PI3K α and β are Class IA PI3K isoforms that share a highly homologous ATP binding site, differing only in a few residues around the binding site.

Funder

Natural Science Foundation of Liaoning Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D0NJ04216A

Reference41 articles.

1. The Phosphoinositide 3-Kinase Pathway

2. The PI3K Pathway in Human Disease

3. Phosphoinositide-3 Kinase Signaling in Cardiac Hypertrophy and Heart Failure

4. Signalling through phosphoinositide 3-kinases: the lipids take centre stage

5. PI3K/Akt signalling pathway and cancer

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