Rose Bengal-photosensitized oxidation of 4-thiothymidine in aqueous medium: evidence for the reaction of the nucleoside with singlet state oxygen

Author:

Rizzi Vito1234,Losito Ilario12345,Ventrella Andrea1234,Fini Paola6734,Fraix Aurore8910114,Sortino Salvatore8910114,Agostiano Angela12346,Longobardi Francesco1234,Cosma Pinalysa12346ORCID

Affiliation:

1. Università degli Studi “Aldo Moro” di Bari

2. Dip. Chimica

3. 4-70126 Bari

4. Italy

5. Centro Interdipartimentale SMART

6. Consiglio Nazionale delle Ricerche CNR-IPCF

7. UOS Bari

8. Laboratory of Photochemistry

9. Department of Drug Sciences

10. University of Catania

11. I-95125 Catania

Abstract

Thymidine and a thiothymidine dimer are the products from the reaction of 4-thiothymidine with 1O2 generated through Rose Bengal-mediated photosensitization.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

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