Synthesis of deuterated γ-linolenic acid and application for biological studies: metabolic tuning and Raman imaging-Reference-Cited by-同舟云学术

Synthesis of deuterated γ-linolenic acid and application for biological studies: metabolic tuning and Raman imaging

Published:2021 Issue:17 Volume:57 Page:2180-2183
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Dodo Kosuke¹²³⁴⁵^ORCID,Sato Ayato¹²³⁴⁵^ORCID,Tamura Yuki¹²³⁴⁵^ORCID,Egoshi Syusuke¹²³⁴⁵,Fujiwara Koichi¹²³⁴⁵,Oonuma Kana⁶³⁴⁵,Nakao Shuhei¹²³⁴⁵^ORCID,Terayama Naoki¹²³⁴⁵^ORCID,Sodeoka Mikiko¹²³⁴⁵^ORCID

Affiliation:

1. Synthetic Organic Chemistry Laboratory

2. RIKEN Cluster for Pioneering Research

3. 2-1 Hirosawa

4. Wako

5. Japan

6. RIKEN Center for Sustainable Resource Science

Abstract

γ-Linolenic acid (GLA) is reported to show tumor-selective cytotoxicity via unidentified mechanisms. We introduced deuterium into GLA as a dual functional tag for metabolic inhibition and Raman imaging and applied for mechanistic studies.

Funder

Japan Society for the Promotion of Science

RIKEN

Japan Agency for Medical Research and Development

Ministry of Education, Culture, Sports, Science and Technology

Core Research for Evolutional Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D0CC07824G

Reference29 articles.

1. Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

2. Radically novel prostaglandins in animals and plants: the isoprostanes

3. The role of n-3 PUFA-derived fatty acid derivatives and their oxygenated metabolites in the modulation of inflammation

4. Tumoricidal action of cis-unsaturated fatty acids and their relationship to free radicals and lipid peroxidation

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