Microbiome–metabolomics analysis reveals the potential effect of verbascoside in alleviating cognitive impairment in db/db mice-Reference-Cited by-同舟云学术

Microbiome–metabolomics analysis reveals the potential effect of verbascoside in alleviating cognitive impairment in db/db mice

Published:2023 Issue:8 Volume:14 Page:3488-3508
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Ran Zheng¹^ORCID,Ju Bowei¹²^ORCID,Cao Lin¹^ORCID,Hou Qiang¹,Wen Limei¹³,Geng Ruoyu¹,Liao Yucheng¹⁴,Hu Junping¹^ORCID,Yang Jianhua³^ORCID

Affiliation:

1. College of Pharmacy, Xinjiang Medical University, Urumqi, 830054, China

2. Department of Pharmacy, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, 830011, China

3. Department of Pharmacy, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, 830011, China

4. Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China

Abstract

Verbascoside treatment ameliorated cognitive and memory deficits in db/db mice by reshaping the gut microbiome composition, alleviating diabetic metabolic disturbances, enhancing insulin sensitivity, and protecting the synaptic ultrastructure.

Funder

National Natural Science Foundation of China

Science and Technology Department of Xinjiang Uyghur Autonomous Region

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D2FO03110H

Reference87 articles.

1. Morphological and Pathological Characteristics of Brain in Diabetic Encephalopathy

2. Cognitive dysfunction in diabetes: how to implement emerging guidelines

3. Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial

4. Risk of Hypoglycemia in Older Veterans with Dementia and Cognitive Impairment: Implications for Practice and Policy

5. Type 2 diabetes and cognitive dysfunction—towards effective management of both comorbidities

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