A carrier free photodynamic oxidizer for enhanced tumor therapy by redox homeostasis disruption-Reference-Cited by-同舟云学术

A carrier free photodynamic oxidizer for enhanced tumor therapy by redox homeostasis disruption

Published:2022 Issue:6 Volume:10 Page:1575-1581
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Yang Ni¹,Zheng Rong-Rong²,Chen Zi-Ying¹,Wang Rui-Xin¹,Zhao Lin-Ping²,Chen Xia-Yun²,Chen Lei³,Xu Lin⁴,Li Shi-Ying²^ORCID,Chen A-Li¹

Affiliation:

1. School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China

2. Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, P. R. China

3. The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, P. R. China

4. Department of Geriatric Cardiology, General Hospital of the Southern Theatre Command, People's Liberation Army (PLA) and Guangdong Pharmaceutical University, Guangzhou 510016, P. R. China

Abstract

In this work, we developed a carrier free photodynamic oxidizer to decrease intracellular glutathione (GSH) levels and disrupt the redox homeostasis for enhanced photodynamic therapy (PDT) efficacy on tumor inhibition.

Funder

National Key Research and Development Program of China

Basic and Applied Basic Research Foundation of Guangdong Province

Guangzhou Municipal Science and Technology Project

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D1BM01876K

Reference27 articles.

1. Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics