Discovery of novel JAK2 and EGFR inhibitors from a series of thiazole-based chalcone derivatives-Reference-Cited by-同舟云学术

Discovery of novel JAK2 and EGFR inhibitors from a series of thiazole-based chalcone derivatives

Published:2021 Issue:3 Volume:12 Page:430-438
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Sanachai Kamonpan¹²³⁴⁵,Aiebchun Thitinan¹²³⁴⁵,Mahalapbutr Panupong²⁶⁷⁸⁹,Seetaha Supaphorn²³¹⁰¹¹⁹,Tabtimmai Lueacha¹²¹³¹⁴¹⁵⁹,Maitarad Phornphimon¹⁶¹⁷¹⁸¹⁹^ORCID,Xenikakis Iakovos²⁰²¹²²²³²⁴,Geronikaki Athina²⁰²¹²²²³²⁴^ORCID,Choowongkomon Kiattawee²³¹⁰¹¹⁹^ORCID,Rungrotmongkol Thanyada¹²³⁴⁵^ORCID

Affiliation:

1. Structural and Computational Biology Research Unit

2. Department of Biochemistry

3. Faculty of Science

4. Chulalongkorn University

5. Bangkok 10330

6. Faculty of Medicine

7. Khon Kaen University

8. Khon Kaen 40002

9. Thailand

10. Kasetsart University

11. Bangkok 10900

12. Department of Biotechnology

13. Faculty of Applied Science

14. King Mongkut's University of Technology of North Bangkok

15. Bangkok

16. Research Center of Nano Science and Technology

17. Shanghai University

18. Shanghai 200444

19. PR China

20. Department of Pharmaceutical Chemistry

21. School of Pharmacy

22. Aristotle University of Thessaloniki

23. Thessaloniki 54124

24. Greece

Abstract

The Janus kinase (JAK) and epidermal growth factor receptor (EGFR) have been considered as potential targets for cancer therapy due to their role in regulating proliferation and survival of cancer cells.

Funder

Thailand Research Fund

Chulalongkorn University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00436G

Reference82 articles.

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4. Janus kinases (JAKs): The efficient therapeutic targets for autoimmune diseases and myeloproliferative disorders

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