Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and esophagus cancer-Reference-Cited by-同舟云学术

Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and esophagus cancer

Published:2021 Issue:4 Volume:12 Page:615-627
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Pereira Nelson A. M.¹²³⁴^ORCID,Laranjo Mafalda⁵⁶⁷²⁸^ORCID,Nascimento Bruno F. O.¹²³⁴^ORCID,Simões João C. S.¹²³⁴⁵^ORCID,Pina João¹²³⁴^ORCID,Costa Bruna D. P.¹²³⁴⁵^ORCID,Brites Gonçalo⁵⁶⁷²⁸^ORCID,Braz João¹²³⁴⁵^ORCID,Seixas de Melo J. Sérgio¹²³⁴^ORCID,Pineiro Marta¹²³⁴^ORCID,Botelho Maria Filomena⁵⁶⁷²⁸^ORCID,Pinho e Melo Teresa M. V. D.¹²³⁴^ORCID

Affiliation:

1. Coimbra Chemistry Centre (CQC) and Department of Chemistry

2. University of Coimbra

3. 3004-535 Coimbra

4. Portugal

5. Institute of Biophysics and Institute for Clinical and Biomedical Research (iCBR)

6. Area of Environment Genetics and Oncobiology (CIMAGO)

7. Faculty of Medicine

8. 3000-548 Coimbra

Abstract

Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins, derived from 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin, as impressive photosensitizers for photodynamic therapy of melanoma and esophagus cancer have been developed.

Funder

European Regional Development Fund

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00433B

Reference55 articles.

1. New photosensitizers for photodynamic therapy

2. Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes