Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and esophagus cancer
Author:
Affiliation:
1. Coimbra Chemistry Centre (CQC) and Department of Chemistry
2. University of Coimbra
3. 3004-535 Coimbra
4. Portugal
5. Institute of Biophysics and Institute for Clinical and Biomedical Research (iCBR)
6. Area of Environment Genetics and Oncobiology (CIMAGO)
7. Faculty of Medicine
8. 3000-548 Coimbra
Abstract
Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins, derived from 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin, as impressive photosensitizers for photodynamic therapy of melanoma and esophagus cancer have been developed.
Funder
European Regional Development Fund
Fundação para a Ciência e a Tecnologia
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00433B
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