Novel cyclometalated iridium(iii) phosphine-imine (P^N) complexes: highly efficient anticancer and anti-lung metastasis agents in vivo-Reference-Cited by-同舟云学术

Novel cyclometalated iridium(iii) phosphine-imine (P^N) complexes: highly efficient anticancer and anti-lung metastasis agents in vivo

Published:2020 Issue:5 Volume:7 Page:1273-1283
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Xu Zhishan¹²³⁴⁵,Yang Yuliang⁶⁷⁸⁹¹⁰,Jia Xianglei¹¹¹²¹³⁵,Guo Lihua⁶⁷⁸⁹¹⁰^ORCID,Ge Xingxing⁶⁷⁸⁹¹⁰,Zhong Genshen¹⁴¹⁵¹⁶¹⁷⁵,Chen Shujiao⁶⁷⁸⁹¹⁰,Liu Zhe⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. College of Chemistry

2. Chemistry Engineering and Materials Science

3. Shandong Normal University

4. Jinan

5. China

6. Institute of Anticancer Agents Development and Theranostic Application

7. The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine

8. Department of Chemistry and Chemical Engineering

9. Qufu Normal University

10. Qufu

11. Henan Key Laboratory of Neural Regeneration

12. The First Affiliated Hospital of Xinxiang Medical University

13. Weihui 453100

14. Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine

15. School of Laboratory Medicine

16. Xinxiang Medical University

17. Xinxiang

Abstract

Iridium(iii)-based complexes with phosphine-imine (P^N) ligands are synthesized and authenticated. The combined treatment with Ir(iii) and BIX01294 potently inhibited tumour growth and lung metastasis in vitro and in vivo.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/QI/C9QI01492F

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