3D cell clusters combined with a bioreactor system to enhance the drug metabolism activities of C3A hepatoma cell lines-Reference-Cited by-同舟云学术

3D cell clusters combined with a bioreactor system to enhance the drug metabolism activities of C3A hepatoma cell lines

Published:2016 Issue:43 Volume:4 Page:7000-7008
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Chen Ching-Yun¹²³⁴⁵,Chiang Tsai-Shin⁶⁷³⁴⁵,Chiou Ling-Ling⁸⁴⁵,Lee Hsuan-Shu⁹³⁴⁵¹⁰,Lin Feng-Huei¹²³⁴⁵

Affiliation:

1. Institute of Biomedical Engineering

2. College of Medicine and College of Engineering

3. National Taiwan University

4. Taipei

5. Republic of China

6. Institute of Molecular Medicine

7. College of Medicine

8. Liver Disease Prevention and Treatment Research Foundation

9. Institute of Biotechnology

10. Department of Internal Medicine

Abstract

Since clinical drugs need to be approved for their liver metabolism efficiency before commercialization, a powerful in vitro drug-screening platform is imperative and indispensable for the clinical medicine and pharmaceutical industries.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2016/TB/C6TB01627H

Reference34 articles.

1. Cytochrome P450 and Chemical Toxicology

2. CYP3A4 Induction by Xenobiotics: Biochemistry, Experimental Methods and Impact on Drug Discovery and Development

3. Transcriptional Regulation and Expression of CYP3A4 in Hepatocytes

4. Drug-induced liver injury: Is it somehow foreseeable?

5. The prediction of drug metabolism using scaffold-mediated enhancement of the induced cytochrome P450 activities in fibroblasts by hepatic transcriptional regulators

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