Heparan sulfate glycomimetics<i>via</i>iterative assembly of “clickable” disaccharides-Reference-Cited by-同舟云学术

Heparan sulfate glycomimeticsviaiterative assembly of “clickable” disaccharides

Published:2023 Issue:13 Volume:14 Page:3514-3522
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yang Cangjie¹,Deng Yu¹,Wang Yang¹,Xia Chaoshuang²^ORCID,Mehta Akul Y.³,Baker Kelly J.³,Samal Anuj¹,Booneimsri Putthipong¹⁴,Lertmaneedang Chanthakarn¹⁴,Hwang Seung¹,Flynn James P.¹,Cao Muqing¹,Liu Chao¹,Zhu Alec C.¹,Cummings Richard D.³,Lin Cheng²,Mohanty Udayan¹,Niu Jia¹^ORCID

Affiliation:

1. Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, USA

2. Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA 02118, USA

3. Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Brookline Ave, Boston, MA 02215, USA

4. Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

Abstract

Iterative assembly of variably sulfated clickable disaccharides facilely produced mass spec-sequencible heparan sulfate mimetics. These glycomimetic oligomers bind protein in a sulfation-dependent manner consistent with that of the native glycans.

Funder

National Science Foundation

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00260H

Reference52 articles.

1. Heparin and heparan sulfate: structure and function

2. Structural diversity of heparan sulfate binding domains in chemokines