A curious case of dynamic disorder in pyrrolidine rings elucidated by NMR crystallography-Reference-Cited by-同舟云学术

A curious case of dynamic disorder in pyrrolidine rings elucidated by NMR crystallography

Published:2020 Issue:90 Volume:56 Page:14039-14042
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Szell Patrick M. J.¹²³⁴^ORCID,Brown Steven P.¹²³⁴^ORCID,Hughes Leslie P.⁵⁶⁷⁸⁴^ORCID,Blade Helen⁵⁶⁷⁸⁴^ORCID,Nilsson Lill Sten O.⁹¹⁰¹¹⁷¹²^ORCID

Affiliation:

1. Department of Physics

2. University of Warwick

3. Coventry

4. UK

5. Oral Product Development

6. Pharmaceutical Technology & Development, Operations

7. AstraZeneca

8. Macclesfield

9. Early Product Development and Manufacturing

10. Pharmaceutical Sciences

11. R&D

12. Gothenburg

Abstract

Pseudosymmetric pyrrolidine groups exhibiting distinct dynamics are investigated by solid-state NMR and DFT, uncovering the origins to this contrast.

Funder

AstraZeneca

Innovate UK

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC05236A

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