Identification of key transporters mediating uptake of aconitum alkaloids into the liver and kidneys and the potential mechanism of detoxification by active ingredients of liquorice-Reference-Cited by-同舟云学术

Identification of key transporters mediating uptake of aconitum alkaloids into the liver and kidneys and the potential mechanism of detoxification by active ingredients of liquorice

Published:2019 Issue:28 Volume:9 Page:16136-16146
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

He Yufei¹²³^ORCID,Wang Ze⁴³,Wu Weidang⁵⁶⁷³,Xie Ying⁸⁹³,Wei Zihong⁵⁶⁷³,Yi Xiulin⁵⁶⁷³,Zeng Yong⁵⁶⁷³,Li Yazhuo⁵⁶⁷³^ORCID,Liu Changxiao¹²³⁵⁶

Affiliation:

1. Shenyang Pharmaceutical University

2. Shenyang City

3. China

4. Tianjin University of Traditional Chinese Medicine

5. State Key Laboratory of Drug Delivery Technologies and Pharmacokinetics

6. Tianjin Institute of Pharmaceutical Research

7. Tianjin

8. State Key Laboratory of Quality Research in Chinese Medicine

9. Macau University of Science and Technology

Abstract

Liquorice may alleviate the toxicity of bioactive ingredients of aconite by inhibiting transporters mediating uptake in the liver/kidneys.

Funder

National Basic Research Program of China

Macau University of Science and Technology Foundation

Natural Science Foundation of Tianjin City

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA00393B

Reference37 articles.

1. Anti-Inflammatory Activity of Diterpene Alkaloids from Aconitum baikalense

2. Pharmacological effects of Chinese herb aconite (Fuzi) on cardiovascular system

3. A review on phytochemistry, pharmacology and toxicology studies of Aconitum

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