Non-competitive inhibitor of nucleoside hydrolase from Leishmania donovani identified by fragment-based drug discovery-Reference-Cited by-同舟云学术

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Non-competitive inhibitor of nucleoside hydrolase from Leishmania donovani identified by fragment-based drug discovery

Published:2016 Issue:90 Volume:6 Page:87738-87744
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Alves M. A.¹²³⁴⁵,Nirma C.¹²³⁴⁵,Moreira M. M.¹²³⁴⁵,Soares R. O.⁶⁷⁸⁵⁹,Pascutti P. G.⁶⁷⁸⁵⁹,Noël F.¹⁰¹¹¹²³¹³,Costa P. R. R.¹⁴¹⁵³⁵⁹,Sant'Anna C. M. R.¹⁰¹¹¹²³¹³,Barreiro E. J.¹⁰¹¹¹²³¹³,Lima L. M.¹⁰¹¹¹²³¹³,Tinoco L. W.¹²³⁴⁵^ORCID

Affiliation:

1. Laboratório de Análise e Desenvolvimento de Inibidores Enzimáticos (LADIE)

2. Instituto de Pesquisa em Produtos Naturais (IPPN)

3. Universidade Federal do Rio de Janeiro

4. Centro de Ciências da Saúde

5. Rio de Janeiro

6. Laboratório de Modelagem e Dinâmica Molecular

7. Instituto de Biofísica Carlos Chagas Filho (IBCCF)

8. Universidade Federal do Rio de Janeiro (UFRJ)

9. Brazil

10. Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos (INCT-INOFAR)

11. Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio®)

12. CCS

13. Cidade Universitária

14. Laboratório de Química Bioorganica (LQB)

15. Instituto de Pesquisas de Produtos Naturais (IPPN)

Abstract

New non-competitive inhibitor of nucleoside hidrolase fromL. donovaniidentified by fragment-based drug discovery using STD NMR and molecular docking.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA15143D

Reference38 articles.

1. P. Y. Nicola , S.Carter, A. S.Cassandra, B. M.Jan and U.Buddy, Drug Targets in Kinetoplastid Parasites, Springer, New York, 2008, pp. 141–154

2. Inhibitors of the Purine Salvage Pathway: A Valuable Approach for Antiprotozoal Chemotherapy?

3. A. K. Datta , R.Datta and B.Sen, Drug Targets in Kinetoplastid Parasites, ed. H. K. Majumder, Springer New York, New York, NY, 2008, pp. 116–132

4. Nucleoside hydrolase from Leishmania (L.) donovani is an antigen diagnostic for visceral leishmaniasis

5. A nonspecific nucleoside hydrolase from Leishmania donovani : implications for purine salvage by the parasite

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