Synthesis, biological evaluation and induced fit docking simulation study of <scp>d</scp>-glucose-conjugated 1H-1,2,3-triazoles having 4H-pyrano[2,3-d]pyrimidine ring as potential agents against bacteria and fungi-Reference-Cited by-同舟云学术

Synthesis, biological evaluation and induced fit docking simulation study of d-glucose-conjugated 1H-1,2,3-triazoles having 4H-pyrano[2,3-d]pyrimidine ring as potential agents against bacteria and fungi

Published:2022 Issue:17 Volume:46 Page:8303-8323
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Son Hai Do¹²,Thi Thu Ha Nguyen¹,Tien Tung Do¹,Thi Kim Giang Nguyen¹²,Thi Thu Huong Nguyen¹,Huu Anh Hoang¹,Thi Kim Van Hoang¹³,Ngoc Toan Vu¹⁴,Toan Duong Ngoc¹⁵,Thanh Nguyen Dinh¹^ORCID

Affiliation:

1. Faculty of Chemistry, VNU University of Science (Vietnam National University, Ha Noi), 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Vietnam

2. Institute of Science and Technology, Ministry of Public Security of Vietnam, 47 Pham Van Dong, Cau Giay, Ha Noi, Vietnam

3. Faculty of Chemical Technology, Viet Tri University of Industry, Tien Kien, Lam Thao, Phu Tho, Vietnam

4. Institute for Chemistry and Materials, Military Institute of Science and Technology (Ministry of Military), Cau Giay, Ha Noi, Vietnam

5. Faculty of Chemistry, Thai Nguyen University of Education, 20 Luong Ngoc Quyen, Thai Nguyen, Vietnam

Abstract

Gluco-conjugated 1H-1,2,3-triazoles having 4H-pyrano[2,3-d]pyrimidines are synthesized via click chemistry of N-propargyl-4H-pyrano[2,3-d]pyrimidines and glucopyaranosyl azide using CuI@Montmorillonite. Their antibacterial, anti-MRSA, and antifungal activity is probed.

Funder

National Foundation for Science and Technology Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D1NJ05330B

Reference54 articles.

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2. 1,2,3-Triazole Tagged 3H -Pyrano[2,3-d ]pyrimidine-6-carboxylate Derivatives: Synthesis, in Vitro Cytotoxicity, Molecular Docking and DNA Interaction Studies

3. Nucleophilic Substitution in Solution: Activation Strain Analysis of Weak and Strong Solvent Effects

4. Cu-Catalyzed Click Reaction in Carbohydrate Chemistry

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