Simultaneous binding mechanism of multiple substrates for multidrug resistance transporter P-glycoprotein-Reference-Cited by-同舟云学术

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Simultaneous binding mechanism of multiple substrates for multidrug resistance transporter P-glycoprotein

Published:2021 Issue:8 Volume:23 Page:4530-4543
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Zhang Bo¹²³⁴^ORCID,Kang Zhengzhong¹²³⁴,Zhang Junqiao¹²³⁴,Kang Yu⁵²⁶⁴^ORCID,Liang Lijun⁷⁸⁹⁴^ORCID,Liu Yingchun¹²³⁴^ORCID,Wang Qi¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Soft Matter Research Center

2. Zhejiang University

3. Hangzhou 310027

4. People's Republic of China

5. College of Pharmaceutical Sciences

6. Hangzhou 310058

7. College of Life Information Science and Instrument Engineering

8. Hangzhou Dianzi University

9. Hangzhou

Abstract

Studying the binding ability of P-gp with multiple drug molecules reveals insights into the promiscuous nature of P-gp.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D0CP05910B

Reference56 articles.

1. BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

2. P-glycoprotein: from genomics to mechanism

3. Simultaneous Binding of Two Different Drugs in the Binding Pocket of the Human Multidrug Resistance P-glycoprotein

4. Determining the Dimensions of the Drug-binding Domain of Human P-glycoprotein Using Thiol Cross-linking Compounds as Molecular Rulers

5. Defining the Drug-binding Site in the Human Multidrug Resistance P-glycoprotein Using a Methanethiosulfonate Analog of Verapamil, MTS-verapamil

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